Hello everyone, today I will be talking about the basic concept of ADME in pharmacology. ADME stands for Absorption, Distribution, Metabolism, and Excretion of drugs in the body. Firstly, let's talk about drug absorption. This refers to the process of a drug entering into the bloodstream from the site of administration, such as the gastrointestinal tract or skin. Factors like solubility, size, and formulation of the drug can affect its absorption rate. Next, drug distribution involves the movement of a drug from the bloodstream to various tissues and organs in the body. This process is influenced by the drug's chemical properties, protein binding, and blood flow to different organs. After distribution, drugs undergo metabolism in the liver, where they are broken down into metabolites that are more easily eliminated from the body. This process can either activate or inactivate the drug, affecting its therapeutic effects. Finally, drug excretion is the removal of drugs and their metabolites from the body, primarily through the kidneys in the form of urine. Other routes of excretion include bile, sweat, and breath. In conclusion, understanding the ADME processes of drugs is crucial for predicting their efficacy and potential side effects in patients. Thank you for listening.